Bio-delivery

Biological childbirth is a unique method, designed by the team of Ac. Prof. Dr. Ljubić, which includes the application of biological therapies during the birth itself. They apply both to the mother and to the newborn child. Biological therapies in pregnancy and childbirth use products of their own cells, prepared using modern technologies. In the prestigious European journal (Journal of Perinatal Medicine) the team of Professor Aleksandar Ljubic recently published a paper that, for the first time, presented an innovative technology of biological regenerative procedures in childbirth. This set of procedures, called Bio-childbirth, is designed to make childbirth safer and reduce maternal and child mortality and disease.

Bio-birth involves the administration of modified substances from one's own blood at different stages of childbirth. The main goal of Bio-birth is to reduce the complications that can occur in the mother (in natural childbirth or caesarean section) and the child (born by caesarean section). The most common complications of the mother are bleeding, infections and impaired healing of injuries and wounds. A child during childbirth by caesarean section does not pass through the vaginal canal of the mother and does not receive the microbial inoculum of the mother at birth, and therefore does not colonize the "beneficial" bacteria, which are considered to participate in the formation of an adequate immune and metabolic system in the earliest months of life. In these children, our goal is to reduce the subsequent occurrence of allergic and skin manifestations, obesity, and autoimmune diseases.Bio-birth involves the administration of modified substances from one's own blood at different stages of childbirth. The main goal of Bio-birth is to reduce the complications that can occur in the mother (in natural childbirth or caesarean section) and the child (born by caesarean section). The most common complications of the mother are bleeding, infections and impaired healing of injuries and wounds. A child during childbirth by caesarean section does not pass through the vaginal canal of the mother and does not receive the microbial inoculum of the mother at birth, and therefore does not colonize the "beneficial" bacteria, which are considered to participate in the formation of an adequate immune and metabolic system in the earliest months of life. In these children, our goal is to reduce the subsequent occurrence of allergic and skin manifestations, obesity, and autoimmune diseases.

Bleeding related to childbirth usually occurs after the birth of a child. Postpartum bleeding is a very serious complication, which can endanger the mother's life. It most often arises from the placental site. The reasons for heavy postpartum bleeding include poor uterine tonus, as well as injuries to the blood vessels of the uterus and surrounding tissues. Bio-delivery, whether vaginal birth or caesarean section, involves the use of bio-regenerative fibrin (BRF) and highly concentrated platelet-enriched plasmas (hcPRP). Both components are obtained from the patient's own blood, which is taken before the onset of childbirth, and therefore are absolutely safe and do not cause immune reactions.

BRF

Bioregenerative fibrin is an autologous product that is obtained from the blood plasma by multiple filtrations during which the proteins necessary for blood clotting are concentrated. BRF is a biodegradable component whose positive effect on the outcomes of surgical procedures is reflected in improving hemostasis, reducing blood loss, and additionally reducing postoperative complications. The newly formed fibrin mesh leads to the cessation of bleeding, a decrease in blood loss, and the need for transfusion of someone else's blood is reduced. If necessary, bioregenerative fibrin is also placed in other places of active surgical bleeding.

During the delivery, BRF stops the bleeding, reduces blood loss, and decreases the requirements for allogeneic blood transfusions. Since it is an autologous product, the administration of BRF does not lead to the initiation of an inflammatory response and there is no risk of getting infections.

hcPRP

Highly concentrated Platelet-enriched plasma is a blood fraction obtained by a special automatised centrifugation process that contains from 4 to 8 times the concentration of platelets compared to full blood. Platelets are blood elements that play a fundamental role in blood coagulation and the healing process of injured tissues. They contain numerous growth factors that support cell proliferation, improve vascularization and exhibit an immunomodulatory effect. Bearing in mind that in PRP platelets are concentrated multiple times, by concentrating platelets in hcPRP, we are actually concentrating the growth factors that are released from platelets, therefore their effect is much more potent.

PRP is applied in places of surgical incisions during c-section. As a matter of fact, during vaginal birth, PRP exerts positive effects in terms of healing pelvic floor micro-injuries, which prevents pelvic floor dysfunction and later pelvic organ prolapse, as well as urinary stress incontinence (inability to control urination).

Autotransfusion

During biological caesarean section, the method of Autotransfusion Intraoperative Blood Salvage is used. The patient's blood is collected during childbirth, processed and later re-infused, which further reduces the need for transfusion of other people's blood products.

Vaginal coating

In addition to the aforementioned biological therapies, bio-birth by cesarean section also includes the so-called "Vaginal coating" of the newborn with the mother's microbiota. Vaginal coating involves exposing children born by caesarean section to the vaginal microbiota. A prerequisite for this procedure is timely microbiologically examined cervical and vaginal microbiological flora with the absence of pathogenic pathogens. Before childbirth, vaginal and cervical swabs are taken, with which a substrate is prepared for coating the newborn, at birth. In a child born by cesarean section, the goal is to reduce the subsequent occurrence of allergic and skin manifestations, obesity, and autoimmune diseases.

In addition to the positive effects of preventive use of bio-birth (reduced blood loss by 25%, reduction of infections and better wound healing), biological regenerative therapies play an important role in addressing urgent and serious, as well as long-term medical complications.

Bio-delivery is designed to reduce the incidence and quantity of bleeding with consecutive massive blood loss, as well as prolonged healing and infection of tissue injuries and wounds. In a child born by C-section, the main objective is to decrease the later appearance of allergic and dermatological issues, obesity and autoimmune diseases.

The main goal of Bio-childbirth is to prevent complications associated with childbirth, as well as optimize childbirth, which shows long-term positive effects on the quality of life, both mother and baby.